Genetically Modified Virus Effective in Cancer Treatment – An Overview

The study published in the journal for Cancer Research states that scientists have developed a new technique in which they use a genetically modified virus for killing cancer cells and even has the ability to destroy their hiding places. Named as the enadenotucirev, this novel dual action virus targets cancer cells as well as the healthy cells that are tricked into cancer cell protection by the immune system of the body called fibro-blasts.

Genetically Modified Virus Effective in Cancer Treatment

The therapy used presently for killing the tricked viruses of cancer may also kill the fibroblast cells leading to toxicity. Carcinomas, the most common kind of cancer are found to start in the cells of the skin or in the tissues covering or lining internal organs like lungs, pancreas, breasts, colon, prostate and ovaries.
As per Kerry Fisher of Britain’s University of Oxford there hasn’t been any way where you can kill the cancer cells and the fibroblasts that are known to protect them as well, without causing any harm to the other parts of the body. Therefore, this technique that can be used for targeting the cancer cells as well as the fibroblasts is definitely cited as a vital development in reducing the suppression inside the carcinomas as well as initiating the normal immune process.

rrmch

The team included some genetic instructions before publishing the study in the journal order the infected cancer cells to produce a protein called bispecific T cell engager, that has the ability to bind and stick two cells together. Here the first end is fibroblasts and the second end is T cells – a kind of immune cell that kills defective cells. The result, T cells started killing attached fibroblasts. The team also carried out the testing of the virus on a human bone marrow successfully to find that the process did not result in creating any toxicity to the rest of the body or any inappropriate activation of T cells.

The clinical trials of Enadenotucirev have already started for carcinoma treatment and in the upcoming year it will begin its clinical trials of finding out the safety and affectivity of it on people suffering from cancer.

 

Just know about Top Cancer Hospitals in Bangalore, Karnataka

 

*Sourced from the Internet

Swimming Can Reduce Mental Stress – An Overview

As per a new study swimming can help reduce symptoms of anxiety or depression. Mental Illness is not a taboo anymore as it used to be in the earlier times. Today mental health is being given as much importance as physical health not only worldwide but in India too. Due to the hectic lifestyles of Indians with extensive workloads and deadlines to match, people suffer from a lot of stress and anxiety. It has already affected millions of people worldwide. Mental health foundation statistics say that in Britain one fifth of the adult population is known to be affected by Mental Health Issues.

Swimming Can Reduce Mental Stress

While discussions are already rife around methods that could help in reducing symptoms of stress and anxiety, there are many different methods and ways coming to light for the same. This includes taking help of mental health professionals, following a proper balanced diet and even swimming. Apparently, an organisation call Swim England carried out a YouGov poll on around 1.4 million adults in UK, to find that Swimming did have a positive effect on their mental health. Almost half a million people of UK who swim and also have faced mental health issues have mentioned that swimming on a regular basis has shown a positive effect and reduced the number of visits they do to the mental health specialist. 43 percent said that swimming made them happy, while 26 percent of the swimmers said that they feel motivated and 15 of them said swimming helps them cope up with the stress that comes along in their daily lives.

As per the head of mental health activities, Hayley Jarvis, engaging into physical activities on a regular basis is good for the body. What the mind says shows the significance of exercising for physical as well as mental well-being. The more active you are physically, the lower are the levels of stress on a daily basis.

This voting campaign was launched on the ‘World Mental Health Day’, as a part of the global initiative in celebrating mental health and creating awareness about reducing the taboo around the same.

As per Ian Cumming, chair of the Swimming and Health Commission in UK, swimming is a very useful activity for the body and research is a good proof of the same. Simply being in water works well for restoration of the body, particularly outdoor swimming. In UK due to the rising population experiencing stress and anxiety issues,

 

The department of Psychiatry at Rajarajeswari Medical College and Hospital strives to achieve and follow “A healthy mind in a healthy body‘. Our dedicated team

 

*Sourced from the Internet

Swine Flu on the Prawl Again – Beware Bengaluru

H1N1 has again begun to spread its wings across Karnataka. Over 207 case have been registered already across the state and a staggering 46 in Bengaluru itself in the past one week. Besides, there are reports of chikungunya and dengue too. The IT corridor of the state particularly the eastern region of the city is badly affected after September 29th, 2018.

As per the health officials, it is worrisome because, these many cases were last reported in 2015. The district surveillance officer clearly stated that the virus was presence in the city and people will low or not immunity are definitely at the risk of catching the life threatening condition.

Swine Flu - H1N1 Flu

A pandemic now, this highly contagious respiratory disorder finds its roots in Mexico in 2009, spreading at a high intensity across the world. The condition is caused through the influenza A virus transmitted from pigs to humans. It can turn out to be a life threatening condition and hence requires great care.

SYMPTOMS
The symptoms of H1N1 are very similar to that of flu –

  • Fever
  • Body aches
  • Sore Throat
  • Stuff or Runny nose
  • Cough
  • Chills
  • Fatigue
  • Headache

Though the symptoms are similar to flu, it can cause serious problems like lung infection, breathing problems and pneumonia. It also has the ability to worsen the health of people suffering from diabetes or asthma. If you observe symptoms like dizziness, severe vomiting, breathing issues, pain in your stomach or sides or confusion, take immediate medical help.

DIAGNOSIS
Only a lab test can confirm the presence of H1N1. For the test, the doctor will use a swab to take samples from inside your nose and throat back. Not every is needs to undergo the test. Only the ones admitted to the hospital and at a high risk of developing the life threatening problems need to do it. These include

  • Children below the age of 5 years
  • Elders above 65
  • Under 18 teens and kids who have been using aspirin
  • Pregnant women
  • Children and Adults with a weak immune system and HIV infected people
  • People housed in nursing homes and care facilities from long

TREATMENT
The antiviral drugs used for treating seasonal flue are used for treatment of H1N1 as well and include medicines like Oseltamivir (Tamiflu), Zanamivir (Relenza), Pearamivir (Rapivab). Some types of swine flu doesn’t respond to Oseltamivir. These drugs are effective and will help you get well soon. The only catch is that they need to be given within 48 hours of the symptoms. Though its not that they don’t work at all but the earlier the better.

Antibiotics won’t work here because it ain’t a bacterial infection, it’s viral. To relieve yourself from headache and body ache you may try over the counter medicines. Avoid giving aspiring to children under 18 because it could increase the risk of Reye’s syndrome. Also, do be careful to check that over the counter medicines you give do not have any content of aspirin.

VACCINE
The vaccine for influenza and swine flu is the same. It’s available as spray or shot form and prepares your body to attack the real virus.

RRMCH is one of Best Hospitals in Bangalore. RRMCH have well experienced doctors. It works 24*7 for all emergency and health care services

 

*Sourced from the Internet

Ductal Carcinoma in Situ (DCIS) & Mastectomy

In India Breast Cancer is the top occurring cancer amongst females with a mortality rate of 12.7 per 1,00,000. A non-invasive form of breast cancer, Ductal carcinoma in situ (DCIS) is a common form of cancer in India. Ductal means ducts as its starts in the milk ducts and carcinoma means cancer that starts in the skin or any other tissues covering the internal organs and in situ means in its original place. The reason this cancer is known as non- invasive cancer is that is has not spread beyond the milk duct to the neighboring tissues.

DCIS is a grade 0 cancer and is not a life threatening cancer but having it in first place does increase the risk of developing an invasive breast cancer later on compared to people who haven’t had it before. The possibility of recurrence is usually 5 or 10 years post the first appearance with a 30% likelihood.

Ductal carcinoma in situ (DCIS)

The possibility of recurrence in women undergoing the breast conserving surgery is around 25% to 30% . To lower the risk of recurrence by 15% you need to include radiation therapy in the treatment plan. Also, if DCIS comes back after treatment it could either be non-invasive or invasive too, chances are 50% for each.

Here’s a look through the symptoms, causes, diagnosis and treatment of the condition.

DICS – Symptoms
Generally there are no visible symptoms of DCIS. Only a few people might have a lump in the breast or some nipple discharge. Diagnosis is only possible for most of the cases through mammography.

DICS – Diagnosis
Breast Examination – A physical examination of breasts is carried out if a lump is present though such lump is rarely noticeable.

Mammography – A mammography can easily detect DCIS. Even when a physical examination fails, mammography can be used to detect DCIS.

Biopsy – Biopsy is only carried out when a mammogram does not give a clear result. There are two kinds of non-invasive biopsies which involve a bit of surgery.

  •  Core needle biopsy – A large needle is inserted for a big sample of tissue from the suspicious area.
  •  Fine needle biopsy – A sample of cells are obtained by inserting a small hollow needle in the breast and then examining it under the microscope.

Though more invasive biopsies are rarely need for DCIS, if the above are not able to give conclusive results then biopsies like incisional and excisional biopsy’s are to be done.

Treatment – Once the diagnosis confirms DCIS, surgery is done to remove the cancer as well as the border of the healthy tissues surrounding the cancer, known as the clear margins. This means doing the procedure of lumpectomy or sometimes mastectomy.

Leptospirosis – The Rat Fever that’s Killing People in Kerala Post Floods

Kerala floods have caused a havoc in kerala washing out villages and towns and post the floods the fear of epidemics is hovering already. Nipah the deadly virus had taken as may has over two dozen lives some months back and now it’s another fever called the rat fever of leptospirosis that has been causing deaths in Gods own country.

Last month a total number of deaths registered in Kozhikode has risen to 17 due to leptospirosis of which 6 have been confirmed and rest are suspected to be due to rat fever. To avoid further spread and even as an immediate measure, 85 bed isolation ward is setup in Kozhikode general hospital as well as government hospitals in Koyilandy, Vadakara and Feroke. Meanwhile low lying Alappuzha and three north-central districts reported a total of nine casualties due to rat fever.

Leptospirosis

The rat fever attacked as many as over 559 people across the state last month already of which 229 were confirmed cases of Leptospirosis.

Here’s a look into the condition, its causes, symptoms, treatment and preventive measures.

Leptospirosis is a condition caused due to a rare bacterial infection caused by a bacteria called Leptospira interrogans and spreads through the urine of animals like rodents, dogs as well as farm stock. These animals never show any symptoms but act as carriers while the organism resides in their kidneys. Although it is not a life threatening disease like Nipah most of the times, there is a possibility of severe leptospirosis which can lead to a fever that returns. When the fever returns, the condition is called Weil’s disease and requires hospitalization because it can have serious symptoms like chest pain, legs and swollen arms.

You can easily contract the bacteria if you are anywhere near to the place where the carrier animal has peed as the germs can invade the body through the scratches, dry areas and open wounds besides genitals, nose or mouth. Human to human infection can only spread to intercourse or breastfeeding.

So, if you are even around animals a lot then you are at high risk of it. Hence, people like veterinarians, underground or sewer workers, farmers, military persons and veterinarians are at high risk of contracting the bacteria. People who are into adventure activities like rafting, camping or swimming.

Symptoms
The symptoms may include fever that can spike up to 104 degrees besides Muscle ache, Headache, Vomiting, Jaundice, Skin Rash and even jaundice.

Diagnosis
The doctor will recommend a blood test and check for antibodies in the blood. Your body will produce antibodies to fight this bacteria but if you have had this condition before, it can give a false positive report. Hence, another test needs to be done for confirmation purpose after one week. The doctor could also advise you to go for a DNA test to be more precise, but it can get expensive to go for this test.

Treatment and Prevention
The treatment course runs across a period of one week where the doctor could prescribe ibuprofen tab for fever and muscle pain besides antibiotics like doxycycline and penicillin. A more serious condition like meningitis, lung issues and kidney failure might require you to get admitted immediately.

As they say prevention is always better, to avoid getting into this mess called Leptospirosis, stay away from domestic animals, live-stock and wild rats.

 

Egg Freezing – More Power to Women

Egg freezing is not an entirely unknown term. Awareness about it is fast spreading across cities in India. Even Gynaecologists have observed a spurt in the inquiries around egg freezing. Scientifically known as oocyte cryopreservation, this process involves the extraction of a woman’s egg from the ovary, freezing and storing it. Afterwards at the time of conceiving, this egg is thawed and placed in the uterus as embryos.

This is a boon for women in India today who want to make life choices on their own at their time. Many women delay marriages as they do not want to get married under pressure and want to prioritize education and career. Such women can freeze their eggs and use them later to conceive. There are numerous case studies to help you understand how egg freezing helped women in India conceive and deliver a healthy baby at a time when they were ready for it.

Case 1 – A 31-year-old female from Matunga wanted to conceive through IVF and her husband was in too much pressure while donating his sperm, so much so that he was not able to produce a semen sample required for the IVF on the day of collection. So, they extracted her egg and froze it. The IVF process was later completed once the semen was received and she had a hassle free pregnancy.

Case 2 – A 14-year-old female was diagnosed with cancer in one of her ovaries. The doctor extracted and froze her egg from the other ovary before she underwent chemotherapy. He mother was glad that her daughter had a choice to conceive in the future as freezing her egg granted protection to her fertility.

Case 3 – A 36-year-old who was not ready for marriage, froze her eggs at 32 so that whenever she is ready for it and for maternity, there are no issues with conceiving.

Today, egg freezing awareness is spreading fast amongst the society and many women are opting for the alternative as it empowers them to make a choice of becoming a mother, at the time they want to. Across the world, egg freezing has already helped conceive and deliver over 2000 babies. Having said that, even though the freezing can be done at any age based on the count of antral follicles and hormone levels, the doctors generally advise doing the egg freezing before 35 years.

In today’s times when the world is embracing gender equality and women are determined to match the abilities of men in almost every walk of life, egg freezing is an amazing addition to their empowerment arsenal.

RRMCH has got best gynecologist in Bangalore and the department provides the best treatment for women health care. RRMCH provides regular clinical services as well.

All You Need to Know About Terminal Illness

The term terminal illness means disease that is not curable and is expected to result in death of the patient over a course of time. It is a commonly used term for illnesses like cancer, heart disease of advanced stage, to name a few. When a person is said to be suffering from a terminal illness, there is near certainty that the patient is going to die in a course of time irrespective of the treatment. Once diagnosed with a terminal condition the patient knows that death is certain and the doctor informs the patient about the time left, in days, weeks, months or years.

Once a patient is diagnosed for terminal illness, the disease management process is decided. The options for it include continual of treatment, caregiving, hospice care and even physician assisted suicide. The decision making is done keeping the patient as well as the family in loop. Many a time patients with terminal illness experience anxiety around the nearing death as well as depression and hence requires psychotherapeutic treatment to help them deal with the same.

On the flip side, knowing about the terminal illness condition gives them time to get ready for advance treatment and care procedures as well as living will, to help them deal with end of life care effectively. Let us run through the different disease management or end of life care procedures for terminal illness patients.

Terminal Illness

Treatment Continuation

Palliative Care – Palliative care is more about after care of the physical needs of the patients post diagnosis. This includes emotional support, management of pain, psychological and spiritual care. It is a methodology that concentrates on improvement of quality of life of the patients and satisfaction besides helping family members deal and cope with the difficult situation.

Care Giving – Care giving is an integral part of terminal disease management. It involves keeping a nurse to take care of the person suffering from the condition. The care givers provide support like psychological support, food, assistance with movement and routine activities on a day to day basis.

Medications – Terminal patients who suffer from cancer related pain, need medications for relief. The medication prescribed varies based on the pain severity as well as status of disease. One of the common symptoms that terminal illness patients experience is dyspnea viz. breathing issues.

Good Hospitals in Bangalore

Hospice Care – There is a misconception that people choosing hospice care live less compared to others, but study has proved that patients with hospice care live for the same span than others. It includes spending more time with family, friends or other inmates undertaking hospice disease management procedures. They usually stay away from a hospital at home or at an inpatient hospice facility.

Physician assisted Suicide (PAS) – This concept is legally approved only in a few countries in the world. It is when a patient decides to die with dignity that he or she opts for physician assisted suicide. The decision could be based on various different reasons like avoiding pain, disability, healthcare costs, family impact, personal and religious beliefs, to name a few. The patient has to give request in writing as well as orally after which the physicians offer them lethal drugs to help them die.

Well, some terminally ill patients stop all the treatments that they are undergoing to avoid side-affects while some go for even more aggressive treatment in a hope to increase their life span to the maximum. Some also opt for alternative methods of treatment that are non-proven as well as diet changes that are required.

What is Food Poisoning? An Overview

Recently, there was news of over 100 prisoners in Delhi falling sick suddenly and being admitted to the hospital. The reason cited for the same is either food poisoning, drug poisoning or contaminated water. Food poisoning is a common term and you hear people and kids suffering from it every now and then. It is a very uncomfortable condition that leads to nausea, vomiting or diarrhea and is caused due to the intake of toxic, contaminated or spoiled food.

Causes
Food poisoning can either be caused by bacteria, viruses or parasites. The most common though is through bacteria like Listeria, E coli and salmonella. The latter is said to be the biggest cause of serious food poisoning cases. Another rare or lethal bacteria responsible for food poisoning includes the C. botulism and Campylobacter. Norovirus is a virus type which can also lead to food poisoning but is not fatal mostly. Others include Rotavirus, Astrovirus, Sapovirus and Hepatitis A, wherein the latter can be serious. Toxoplasma is a parasite which causes food poisoning. Parasites live within your digestive tract but can go undetected for years.

Food-Poisoning-Main-blog-image-550x410

Symptoms
Usually, food poisoning is detectable based on the symptoms. The symptoms differ as per the infection source. The symptoms appear anytime within 1 hour or 28 days depending on the infection source again. Most people suffering from food poisoning show atleast three of the following symptoms.

  • Headache
  • Weakness
  • Nausea
  • Mild fever
  • Loss of appetite
  • Diarrhea
  • Abdominal cramps

Food poisoning ain’t life-threatening. But, this does not mean that you take the condition lightly. There is always a rare possibility of it getting life-threatening as well. Look out for the following symptoms and initiate immediate medical assistance –

  • Fever of 105 or higher
  • Severe dehydration, dry mouth, no urine passage
  • Difficulty speaking or seeing
  • Diarrhea that does not go for 3 or more days
  • Blood in urine

Treatment
Food poisoning generally does not require any treatment and can easily be managed at home. It can take three to five days to subside but the most important part is to stay hydrated all along. Consumption of Sports drink that has electrolyte in them works really well in dealing with the condition. To help yourself out of fatigue try natural drinks like coconut water and fruit juice.

Know about best Hospitals in Bangalore, Karnataka.

Top 5 Ongoing Trends in Healthcare Sector

Gone are the times when healthcare sector had a reputation of almost negative customer experiences. Nowadays, healthcare companies are going all guns blazing about their approach towards their customers. The approach also includes the optimum use of advanced technology besides newer approaches in-order to create a progressive change in the healthcare industry. Let us run through some of the upcoming trends in the healthcare eco-system.

Trends in Healthcare Sector

Tailored Medicine – Medicine is all about observation based diagnosis with evidence to support the same. Today, healthcare centers are equipped with the latest in technology that results into accurate and speedy diagnosis. For example, with the help of radiology clinicians can investigate structures deep inside the body and with techniques like histopathology, clinicians can identify virus and tumors using microscopes.

Virtual Reality – Virtual reality is working well in the management and treatment of pain. As per a study of the recent times, children responded to chemotherapy better when they played games while undergoing the same. This was because their attention got concentrated from the treatment part to the play part and hence even resulted in them requiring less dosage. Side effects like nausea and hypertension were also reduced compared to children who were advised to rest.

Patient Customization – Data has grown and so has the ability of the healthcare facilities to provide their customers with an experience that is absolutely personalized. Based on the history of the patient, these clinics provide facilities like potential health issues, doctors preferred by the patient, patient preference in terms of remote treatment or walk in, to name a few. This can help avoid the complexities involved with the navigation through health care professional web and makes patients information available readily for speedy and accurate treatment solutions.

Augmented Reality – Besides other fields, augmented reality is playing a crucial role in healthcare and is fast turning out to be one of the most effective applications in medical training. AR helps doctors while monitoring diagnosis with the treatment procedure options to look forward too. They don’t have to spend time in honing their medical knowledge further because treatment options can simply pop up on their screen with options and suggestions. For example, while doing a child checkup the growth chart can pop up on the monitor itself, thus helping the doctor with seamless treatment procedures.

Smart Technology in HospitalsSmart Technology in Hospitals has actually helped better patient experience, comfort, and care. For example, many hospitals have started using smart technology in hospitals. In a few countries, certain healthcare outfits use self-adjusting beds for pressure and support customization for patients. Many are also making use of man free facilities where robots carry out the monitoring process of the patient in the room. Smart technology is available in different forms and works in reducing risks while increasing comfort and efficiency. Affirmatively, the use of smart technology across the healthcare ecosystem is poised to grow day by day, obviously so.

All you need to Know About HLA-B27 Test

HLA B27 is a test that is conducted to identify the Human Leukocyte Antigen (HLA B27) protein. This protein is situated on the white blood cells surface and is an antigen that helps the immune system infection causing aliens and healthy body tissues.

Though most of the HLAs protect the body against harmful invaders, HLA B27 is on a particular protein that is responsible for system dysfunction by attacking the healthy cells instead of foreign substances. This causes autoimmune diseases like ankylosing spondylitis or rheumatoid arthritis.

HLA B27

Symptoms that indicate Test Taking
The HLA-B27 test is taken alongside other tests like MRI scan, urine and blood tests to confirm the presence of autoimmune disease.

  • Joint inflammation and skin lesions
  • Pain in the joints
  • Eye inflammation that reoccurs
  • Swelling or stiffness in the neck, chest or spine

Auto-immune conditions due to HLA-B27
Based on the symptoms the doctor may advise the test to check for the presence and progression of HLA-B27 with certain autoimmune conditions like

  • Bone inflammation in the spine – Ankylosing spondylitis
  • Joint inflammation in joints, eyes, urethra, and skins lesions at times – Reactive arthritis
  • Swelling and irritation at eyes middle layer – Anterior uveitis
  • Joint stiffness, pain, redness, limping, swelling and reduced motion range – Juvenile rheumatoid arthritis

Besides, HLA antigen tests are also taken when a patient needs to undergo a transplant of kidney or bone marrow as they help in determining a suitable match of a donor.

Diagnosis
If the test is positive, it indicates the presence of HLA- B27 in blood. Though, it still is not a cent percent confirmation that an autoimmune condition may develop. Other symptoms are also taken into account including blood tests and diagnostic exams.

Conclusion
HLA-B27 indicates the presence of the protein in blood but a positive or negative result cannot be taken as a cent percent confirmation of the autoimmune disorder. Once the test is done and the results are out, the doctor will advise you on further steps around the possible condition.

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