Genetically Modified Virus Effective in Cancer Treatment – An Overview

The study published in the journal for Cancer Research states that scientists have developed a new technique in which they use a genetically modified virus for killing cancer cells and even has the ability to destroy their hiding places. Named as the enadenotucirev, this novel dual action virus targets cancer cells as well as the healthy cells that are tricked into cancer cell protection by the immune system of the body called fibro-blasts.

Genetically Modified Virus Effective in Cancer Treatment

The therapy used presently for killing the tricked viruses of cancer may also kill the fibroblast cells leading to toxicity. Carcinomas, the most common kind of cancer are found to start in the cells of the skin or in the tissues covering or lining internal organs like lungs, pancreas, breasts, colon, prostate and ovaries.
As per Kerry Fisher of Britain’s University of Oxford there hasn’t been any way where you can kill the cancer cells and the fibroblasts that are known to protect them as well, without causing any harm to the other parts of the body. Therefore, this technique that can be used for targeting the cancer cells as well as the fibroblasts is definitely cited as a vital development in reducing the suppression inside the carcinomas as well as initiating the normal immune process.

rrmch

The team included some genetic instructions before publishing the study in the journal order the infected cancer cells to produce a protein called bispecific T cell engager, that has the ability to bind and stick two cells together. Here the first end is fibroblasts and the second end is T cells – a kind of immune cell that kills defective cells. The result, T cells started killing attached fibroblasts. The team also carried out the testing of the virus on a human bone marrow successfully to find that the process did not result in creating any toxicity to the rest of the body or any inappropriate activation of T cells.

The clinical trials of Enadenotucirev have already started for carcinoma treatment and in the upcoming year it will begin its clinical trials of finding out the safety and affectivity of it on people suffering from cancer.

 

Just know about Top Cancer Hospitals in Bangalore, Karnataka

 

*Sourced from the Internet

All You Need to Know About Ganglion Cyst

Many of you might not have heard about this condition but it does exist and is a common condition for the age group of 20 to 40 years. A ganglion cyst is a tumor or swelling caused either on the tendon viz. the tissue that connects muscle to the bone or the top of a joint. The cyst is sticky and colourless and looks like a sac of liquid. The size of the cyst may vary and it could feel spongy as well. There could either be on single cyst or one large one and multiple number of smaller ones around it connected by a common stalk within the deeper tissue. Also known as Bible cyst, is not harmful and around 70% people experience it in their lifetime. Ganglion cysts are very rare in age-groups less than 10 years. Ganglion cysts usually develop on the back of the hand. They are found at the joint of the wrist but can also be seen on the side of the palm. The other rare but possible sites of cyst include mucous cysts occurring right below the cuticle on the fingertip, the foot top, as pea sized bumps on the palm finger base, as well as the outer part of the ankle as well as the knee.

Ganglion Cyst

Causes
As on day the causes of the cyst are not known. As per doctors it could be due to breakdown of the tissue joint as a result of some trauma. Another theory mentions joint capsule fault or in that of the tendon sheath leading to joint tissue bulge.

Symptoms

  • If you have a bulge or bump of changing mass.
  • If the diameter is 1-3 cm and it does not move
  • There is a sudden swelling or a gradual one
  • If it is recurring after a certain period of time
  • Ganglion cysts do cause pain followed by acute trauma even if they don’t appear.
  • If it pains it could get worse due to joint motion
  • In cysts that are connected to the tendon, you feel weakness in the finger

Medical Advice
Medical evaluation of the cyst is important whether or not you have all the symptoms. This will help the doctor in making it sure and offering a suitable line of treatment. The doctor could advise on an ultrasound or test using the cyst fluid. At times even a MRI could be advised by the doctor though it is an expensive procedure.

Treatment
Ganglion Cysts can be treated with hot bags at home. Sometimes if there is pain, doctor may prescribe a pain killer as well. Surgical or cosmetic removal of cysts of bigger size can be done but they could reoccur as well.

 

 

Rajarajeswari Hospital having high specialised Orthopedic Doctors in Bangalore

 

*Sourced from the Internet

Swimming Can Reduce Mental Stress – An Overview

As per a new study swimming can help reduce symptoms of anxiety or depression. Mental Illness is not a taboo anymore as it used to be in the earlier times. Today mental health is being given as much importance as physical health not only worldwide but in India too. Due to the hectic lifestyles of Indians with extensive workloads and deadlines to match, people suffer from a lot of stress and anxiety. It has already affected millions of people worldwide. Mental health foundation statistics say that in Britain one fifth of the adult population is known to be affected by Mental Health Issues.

Swimming Can Reduce Mental Stress

While discussions are already rife around methods that could help in reducing symptoms of stress and anxiety, there are many different methods and ways coming to light for the same. This includes taking help of mental health professionals, following a proper balanced diet and even swimming. Apparently, an organisation call Swim England carried out a YouGov poll on around 1.4 million adults in UK, to find that Swimming did have a positive effect on their mental health. Almost half a million people of UK who swim and also have faced mental health issues have mentioned that swimming on a regular basis has shown a positive effect and reduced the number of visits they do to the mental health specialist. 43 percent said that swimming made them happy, while 26 percent of the swimmers said that they feel motivated and 15 of them said swimming helps them cope up with the stress that comes along in their daily lives.

As per the head of mental health activities, Hayley Jarvis, engaging into physical activities on a regular basis is good for the body. What the mind says shows the significance of exercising for physical as well as mental well-being. The more active you are physically, the lower are the levels of stress on a daily basis.

This voting campaign was launched on the ‘World Mental Health Day’, as a part of the global initiative in celebrating mental health and creating awareness about reducing the taboo around the same.

As per Ian Cumming, chair of the Swimming and Health Commission in UK, swimming is a very useful activity for the body and research is a good proof of the same. Simply being in water works well for restoration of the body, particularly outdoor swimming. In UK due to the rising population experiencing stress and anxiety issues,

 

The department of Psychiatry at Rajarajeswari Medical College and Hospital strives to achieve and follow “A healthy mind in a healthy body‘. Our dedicated team

 

*Sourced from the Internet

Zika Virus – Symptoms, Causes and treatment

Recently, Zika virus has taken a toll in Jaipur with over 42 confirmed cases. A fatal virus, Zika finds its roots in Uganda, where it was discovered in the year 1947. The same mosquito responsible for tracing yellow fever, chikungunya and dengue virus is known to transmit Zika. Thought it can be transmitted through the following besides mosquito –

  • Pregnant women to her unborn child
  • Blood Transfusion
  • Sexual intercourse
  • Possibly through saliva while kissing (may or may not)

Zika virus can cause various disorders/ Complications like Premature birth, severe dehydration, hearing impairment, eye problems in infants, Acute Disseminated Encephalomyelitis (ADEM) and the following as well –

Zika Virus - Symptoms, Causes and treatment

Congenital malformations
When the virus is transmitted to the unborn child through a pregnant woman, it is bound to attack the nervous system of the child and cause microcephaly or prevent brain growth. It may damage the fetus, which could not be visible immediately but many years of birth. This virus is present in the milk of an infected mother as well.

Guillain Barre Syndrome
After the Zika virus enters the nervous system, some people tend to suffer from a disorder known as Guillain Barre Syndrome. It can also get into the brain and cause other neurological symptoms. This virus has the ability to not directly attack but get the immune system to attack the nervous system.

Symptoms
The symptoms of people infected by Zika include the following

  • Fever
  • Joint pain
  • Rash
  • Nausea
  • Headache
  • Conjunctivitis
  • Chills
  • Bloodshot eyes
  • Sweating
  • Cheek Swelling

Diagnosis
The diagnosis of Zika can be done using a blood, saliva , semen and urine test.

Zika Treatment
As on date there is not treatment or vaccination available for Zika. You only can treat the symptoms using fever reducers and medicines for reducing vomiting or rash.

*Sourced from the Internet

Swine Flu on the Prawl Again – Beware Bengaluru

H1N1 has again begun to spread its wings across Karnataka. Over 207 case have been registered already across the state and a staggering 46 in Bengaluru itself in the past one week. Besides, there are reports of chikungunya and dengue too. The IT corridor of the state particularly the eastern region of the city is badly affected after September 29th, 2018.

As per the health officials, it is worrisome because, these many cases were last reported in 2015. The district surveillance officer clearly stated that the virus was presence in the city and people will low or not immunity are definitely at the risk of catching the life threatening condition.

Swine Flu - H1N1 Flu

A pandemic now, this highly contagious respiratory disorder finds its roots in Mexico in 2009, spreading at a high intensity across the world. The condition is caused through the influenza A virus transmitted from pigs to humans. It can turn out to be a life threatening condition and hence requires great care.

SYMPTOMS
The symptoms of H1N1 are very similar to that of flu –

  • Fever
  • Body aches
  • Sore Throat
  • Stuff or Runny nose
  • Cough
  • Chills
  • Fatigue
  • Headache

Though the symptoms are similar to flu, it can cause serious problems like lung infection, breathing problems and pneumonia. It also has the ability to worsen the health of people suffering from diabetes or asthma. If you observe symptoms like dizziness, severe vomiting, breathing issues, pain in your stomach or sides or confusion, take immediate medical help.

DIAGNOSIS
Only a lab test can confirm the presence of H1N1. For the test, the doctor will use a swab to take samples from inside your nose and throat back. Not every is needs to undergo the test. Only the ones admitted to the hospital and at a high risk of developing the life threatening problems need to do it. These include

  • Children below the age of 5 years
  • Elders above 65
  • Under 18 teens and kids who have been using aspirin
  • Pregnant women
  • Children and Adults with a weak immune system and HIV infected people
  • People housed in nursing homes and care facilities from long

TREATMENT
The antiviral drugs used for treating seasonal flue are used for treatment of H1N1 as well and include medicines like Oseltamivir (Tamiflu), Zanamivir (Relenza), Pearamivir (Rapivab). Some types of swine flu doesn’t respond to Oseltamivir. These drugs are effective and will help you get well soon. The only catch is that they need to be given within 48 hours of the symptoms. Though its not that they don’t work at all but the earlier the better.

Antibiotics won’t work here because it ain’t a bacterial infection, it’s viral. To relieve yourself from headache and body ache you may try over the counter medicines. Avoid giving aspiring to children under 18 because it could increase the risk of Reye’s syndrome. Also, do be careful to check that over the counter medicines you give do not have any content of aspirin.

VACCINE
The vaccine for influenza and swine flu is the same. It’s available as spray or shot form and prepares your body to attack the real virus.

RRMCH is one of Best Hospitals in Bangalore. RRMCH have well experienced doctors. It works 24*7 for all emergency and health care services

 

*Sourced from the Internet

On World Heart Day Decide on a Healthy Oil for Cooking

It is not secret that India tops the list of mortalities due to cardiac arrests and diseases. The reasons obviously point out to many, and unhealthy lifestyle is one of the main ones. A healthy lifestyle is an amalgamation of a balanced diet, a fitness regime that is followed on a regular basis and addiction free. As per a leading nutritionist, though food forms a significant part of your lifestyle, it’s not just about the type of food that is consumed. A lot of things are associated with food, it’s the way the food is cooked, served, consumed as well as the time when you consume it.

On World Heart Day Decide on a Healthy Oil for Cooking

Also, when anyone says oil, everyone seems to be rolling their eyes because, we feel that the real culprit of your unhealthy body is the oil. But, the fact is that oil is not bad as you would imagine it to be. It is a mix of different kinds of fats. Also, a healthy oil is a mixture of different kinds of fats. Hence, when you select your oil, it’s important that you check for a balance between the essential fats of it.

Here are a few tips to help you out with selection of a healthy oil for healthy cooking –

Loaded with Mono-saturated Fats – Mono-saturated fats are good for health and hence it’s good to choose an oil that is rich in mono-saturated fats. These fats solidify when kept in the fridge and transform into liquid when at room temperature.

More of Polyunsaturated fats – Poly unsaturated fats contain Omega 3 and Omega 6, which happen to be vital for the body. We all know that omega 3 is responsible for protecting our body against inflammation, thus protecting us against diseases. Our body is not capable of producing them and hence we need it to be there in our diet. Though Omega 3 is what we need more than omega 6, precisely in a ratio of 1:2 or 1:4.

Less of Trans Fats – Trans-fat are highly harmful to the body. To say the least, its best to avoid this fat. Trans-fats are formed when poly-saturated fats are transformed into solid. These fats are leading causes of heart diseases, high cholesterol as well as cancer.

Less of Saturated Fats– Saturated fats are known to be bad fat but apparently they come under the neutral category. You can have an intake of saturated fat but in limit. They are good but not as good as mono-saturated fat. Also, the bad saturated fats are the hydrogenated saturated fats that are man-made.

Lastly, fat is bad only when it is consumed in a quantity that is more than required. So, controlling eating habits is the key to healthy body.

 

RajaRajeswari hospital is having one of the best Cardiologist in Bangalore, It provides all types of cardiology services with cutting edge facilities advance cardiac

 

*Sourced from the Internet

Lips Don’t Lie – Aging Signs

We all are aware that the preliminary signs of aging start around your eyes. But, we aren’t aware of another fact that is lips also don’t lie. When you age lips start losing their volume and this also falls under the preliminary sign of aging. Apparently, if you do not take care of your lips, it could result in premature aging making you look aged even if you ain’t due to the thining of them.

Well, you may ask, the reason about lips aging away. Here’s what you need to know.

Exposure to Sunlight – UV rays can take quite a toll on your lips as they are exposed to sunlight and are highly delicate in nature.

Inadequate moisturization – Compared to the skin which has 16 cellular layers, the lip has only five. Hence, the lips are more vulnerable to deterioration comparatively and if not hydrated adequately can cause damage.

Addictions like Smoking – Addictions like smoking can cause unrepairable damage to your lips. This is because the toxins, tar as well as the nicotine present in cigarettes. They can not only cause discoloration but also cause coarse fine lines and deep wrinkles around the mouth.

Continuous lip licking – If you think that licking is a natural way of moisturizing your lips when you run out of a moisturizer but the fact is, lip licking causes more harm than good. It dries the already dry lips further besides removing the natural oil of your lips.

Collagen depletion around localized region – Collagen is responsible for protection of the skin against possible signs of ageing. Collagen is the foundation for hyaluronic and elastin acids, that play a significant role in keeping the shape, structure as well as suppleness of the lips up to date. Loss of collagen can also lead to loss in lip elasticity and volume as well.

Treatment – In order to keep the lips in shape, both men and women are trying lip fillers. These fillers are also called Hyaluronic acid fillers as they help in retaining the shape, volume and structure of fillers magically. The filler consists of gel which has to be injected in the lips. Once it is done this gel helps in supporting the lips tissues. It is popular because it is non-invasive and is also priced per syringe.

 

Know more about Cosmetic Surgery in Bangalore

 

*Sourced from the Internet

Ductal Carcinoma in Situ (DCIS) & Mastectomy

In India Breast Cancer is the top occurring cancer amongst females with a mortality rate of 12.7 per 1,00,000. A non-invasive form of breast cancer, Ductal carcinoma in situ (DCIS) is a common form of cancer in India. Ductal means ducts as its starts in the milk ducts and carcinoma means cancer that starts in the skin or any other tissues covering the internal organs and in situ means in its original place. The reason this cancer is known as non- invasive cancer is that is has not spread beyond the milk duct to the neighboring tissues.

DCIS is a grade 0 cancer and is not a life threatening cancer but having it in first place does increase the risk of developing an invasive breast cancer later on compared to people who haven’t had it before. The possibility of recurrence is usually 5 or 10 years post the first appearance with a 30% likelihood.

Ductal carcinoma in situ (DCIS)

The possibility of recurrence in women undergoing the breast conserving surgery is around 25% to 30% . To lower the risk of recurrence by 15% you need to include radiation therapy in the treatment plan. Also, if DCIS comes back after treatment it could either be non-invasive or invasive too, chances are 50% for each.

Here’s a look through the symptoms, causes, diagnosis and treatment of the condition.

DICS – Symptoms
Generally there are no visible symptoms of DCIS. Only a few people might have a lump in the breast or some nipple discharge. Diagnosis is only possible for most of the cases through mammography.

DICS – Diagnosis
Breast Examination – A physical examination of breasts is carried out if a lump is present though such lump is rarely noticeable.

Mammography – A mammography can easily detect DCIS. Even when a physical examination fails, mammography can be used to detect DCIS.

Biopsy – Biopsy is only carried out when a mammogram does not give a clear result. There are two kinds of non-invasive biopsies which involve a bit of surgery.

  •  Core needle biopsy – A large needle is inserted for a big sample of tissue from the suspicious area.
  •  Fine needle biopsy – A sample of cells are obtained by inserting a small hollow needle in the breast and then examining it under the microscope.

Though more invasive biopsies are rarely need for DCIS, if the above are not able to give conclusive results then biopsies like incisional and excisional biopsy’s are to be done.

Treatment – Once the diagnosis confirms DCIS, surgery is done to remove the cancer as well as the border of the healthy tissues surrounding the cancer, known as the clear margins. This means doing the procedure of lumpectomy or sometimes mastectomy.

Be Aware of the Silent Killer Called Ovarian Cancer

Many women aren’t aware that ovarian cancer is also known as the Silent Killer because generally no visible symptoms indicate the presence of this cancer and the symptoms surface only during the final stages. This cancer has known to affect as many as over 20K women across the world every year and due to the lack of visible symptoms indicating the cancer, it makes this cancer even scarier.

CAUSES AND RISKS
The causes of this cancer are not clear as yet but family history is one of the risk factors and the women having a family member or relative with ovarian cancer or breast cancer are definitely at a higher risk of the same. Age can also be termed as one of the risk factors because most women get it after 60 -63 years. Also, the women who have had one or more pregnancies before the age of 26 are at a lower risk. The risk is lower if the number of pregnancies is higher. Even using contraceptives frequently tends to lower the risk of ovarian cancer. As per doctors there is this contraceptive hormone called DMPA or Depo pro-vera CI that if injected of more than 3 years, reduces the risk of ovarian cancer even further. Women who make use of infertility treatment drugs over a period of one year are also known to have a high risk of getting ovarian cancer. Other risk factors include obesity, hormone therapy and gynecologic surgery as in surgery of reproductive organs and getting endometriosis at the age of 30 years.

Ovarian Cancer

DIAGNOSIS AND STAGES
The doctor on examination will ask for some tests that include blood test, a CT scan or MRI as well as Laparoscopy, biopsy, abdominal fluid aspiration test or colonoscopy for that matter.

Stages
As per the American Cancer society ovarian cancer has four stages
Stage 1 – This is the preliminary stage of ovarian cancer where only the ovary or the ovaries are affected.
Stage 2 – This is the secondary stage where the cancer is out of the ovaries and spread around the areas like fallopian tubes, uterus, rectum or the bladder.
Stage 3 – This is a later stage of cancer where the cancer affects the lymph nodes, abdominal lining or even the back of the abdomen.
Stage 4 – The last stage of cancer where the cancer has spread to other parts of the body outside the peritoneal cavity viz. abdomen or pelvis upto the liver, fluid around the lungs or the spleen.

SYMPTOMS
The initial symptoms of ovarian cancer are easy to miss because they are very much similar to premenstrual syndrome. So, you have to be alert and if you find any of the below mentioned symptoms that persist for a long time then good idea is to go for checkup.

Recurring Abdominal Pain
If you have been experiencing stomach ache for a long time even if you don’t have your monthly cycles then its time you get it tested.

Appetite loss and Nausea
When ovarian cancer starts spreading around, it affects the bowel system and causes nausea. If you feel you have been experiencing and loss in your appetite or feeling full sooner than ever, check it out.

Bloating and Constipation
When a tumor is growing inside you even when you do not eat much you feel fuller and bloated. It can also affect your bowel movement leading to regular constipation issues.

Irregular monthly cycles
A tumor in the ovary will cause your monthly period to become irregular or sorts. So, if you haven’t been experiencing any irregularity in your monthly periods earlier but only lately for a while, good idea to meet up with your doctor.

Frequent urination
If you have been making frequent trips to the bathroom for peeing then this could be the sign. Do not ignore and visit your doctor.

TREATMENT
The treatment is based on the diagnosis of the stage of the cancer and includes procedures like surgery, chemotherapy, radiation therapy, targeted therapy as well as hormonal therapy. One or more treatments in combination are usually used depending upon the stage of the cancer.

Surgery types
The extent of surgery is also based on the stage and includes removal of ovaries, fallopian tubes, uterus as well the affected surrounding tissues. Then there is de-bulking surgery and lymph node dissections also which is done to reduce the cancerous tissues if the cancer is spread beyond the pelvic region and removal of lymph nodes near the aorta respectively.

Therapy types
Chemotherapy is generally done post-surgery to kill the remaining cancer cells. A medication known as cytotoxic medication poisonous drugs to the cells in-order to prevent growth and division. This is a recurring process based on the cancer growth. Targeted Chemotherapy is another treatment that involves target specific function or pathways of cancer cells. Another therapy that is used as a part to treatment is Hormone therapy. It is done to cut the supply of estrogen from the cancer cells in order to slow their growth. Radiation therapy is also used for treatment of cancer and is generally used in advanced form of cancer.

Survival
As the stage increases the survival rate decreases. While for Stage I there is a 90% chance of survival, for stage IV, the chance is 17%.

Know more about Best Cancer Hospital in Bangalore

 

*Sourced from the Internet

Compulsive Doing Syndrome – Do you Have It?

Do you feel that you are very busy and occupied most of the times. Do you answer in a negative when someone asks you to meet up, hangout or for any other meet? Is the answer to most questions about availability as ‘Sorry, Busy’. Then, you have a compulsive doing syndrome. The symptoms of this syndrome include –

Compulsive Doing Syndrome

  • No time for family affairs
  • Not time to eat
  • Your to do list goes on increasing
  • Sleepless nights for a long time
  • You might seem busy and hardworking but nothing out of the box

Now, for the reason. This syndrome is because we are brought up believing that being busy means being worthy. This is the most common causes of Compulsive doing syndrome too.

Another reason is that we tend to overburden ourselves until there is no time left for anything to fit in. Many times it can be a sign of running away from problems, situations and issues. So, if you feel that you are busy all the time, know it once and for all that it is apparently a lifestyle issue and needs to be worked up.

Being over occupied without any time to spare apparently show that your time management skills are not good enough. Besides, it also points to clarity or work and focus issues. If you are focused on your work you can finish off your work faster and ample time left for other priorities.

Exercising Breathing for 5 minutes every day helps you calm down, distress and relax. Doing it will certainly help you manage yourself better. Have time allocated for activities that help you feel well mentally, physically and spiritually. Could be a jog, or exercise or music or some extra-curricular activity.

Try to get away from gadgets be it your phone, laptop or television and concentrate on eating while having your meals. Give your family the attention they deserve and not non-living objects over them. Sparing some time out for meditation is definitely a food idea for mental health and overall wellness.

Well, compulsive doing syndrome can be worked up if you are willing to understand that being busy is very much about time management, concentration and clarity.